Guasave is a city located in the northwestern part of Mexico within the state of Sinaloa. It serves as the seat of the homonymous municipality, which is widely recognized as the Agricultural Heart of Mexico.
The city is situated at coordinates 25°34′04.5″N 108°28′10.8″W. Geographically, it lies approximately 62 kilometers southeast of the city of Los Mochis and about 150 kilometers northeast of Culiacán, the state capital.