San Andrés Cholula is the municipal seat of San Andrés Cholula Municipality, situated in the Metropolitan area of Puebla within the central highlands of Mexico. Located approximately 122 kilometers east of Mexico City and eight kilometers west of the city of Puebla, it constitutes one of the two municipalities that form the modern city of Cholula, or Cholula de Rivadavia.
The region has been divided into two parts since the pre-Hispanic period following a revolt by the Toltecs-Chichimecas. This division separates the area containing the Great Pyramid of Cholula to the east from the western side. Despite this historical split, the two halves maintain shared religious and social traditions.
San Andrés Cholula is characterized by its significant indigenous population and its collection of colonial-era churches. These structures are frequently decorated with Talavera tile in a style known as Indigenous or Folk Baroque, with the church in the Santa María Tonatzintla community serving as a prominent example of this architecture.