Santo Domingo Tepuxtepec is a town and municipality located in the state of Oaxaca in southwestern Mexico. It is situated within the Sierra Norte de Oaxaca Region and serves as part of the Sierra Mixe district.
The municipality is characterized by its location in the mountainous terrain of the Sierra Mixe region. While specific geographic dimensions are noted as being part of the regional landscape, it remains a distinct administrative and local entity within the state's southern highlands.