Santa María Xadani is a town and municipality located in the state of Oaxaca in southwestern Mexico. It is situated within the Juchitán District, which lies in the western portion of the Istmo de Tehuantepec region.
The area is characterized by its geographical position within the Isthmus of Tehuantepec, a significant land bridge connecting the Gulf of Mexico and the Pacific Ocean. As a municipality, it serves as a local administrative division within the state's regional infrastructure.