Santa María Guelacé is a town and municipality located in the state of Oaxaca in south-western Mexico. It is situated within the Tlacolula District, which lies in the eastern portion of the Valles Centrales Region.
The municipality occupies a specific area within this region of Oaxaca. While it serves as a local administrative and residential hub, its geographical identity is defined by its placement within the broader cultural and agricultural landscape of the Valles Centrales.