Nuevo Casas Grandes is a city and the seat of the Nuevo Casas Grandes Municipality located in northern Mexico. It is situated in the northwestern portion of the state of Chihuahua.
The city is positioned on the Casas Grandes or San Miguel river within a wide, fertile valley on the 4,000-foot Mesa del Norte of the Plateau of Mexico. The area is located near the Sierra Madre Occidental mountain range.