Centerville is a city located in the state of Iowa, United States. It serves as the county seat for Appanoose County. According to the 2020 census, the city had a population of 5,412, reflecting a decrease from the 5,924 residents recorded in 2000.
The city's history is marked by its coal mining industry, which drew significant numbers of European immigrants from countries including Sweden, Italy, Croatia, and Albania after the turn of the 20th century. Centerville is also notable for hosting the largest town square in the state of Iowa and a campus of Indian Hills Community College.