Harmanli is a city located in Adıyaman Province in southeastern Turkey. It is situated in the region historically known as Upper Mesopotamia, in an area characterized by rolling terrain and agricultural land.
The city serves as a local administrative and commercial center for the surrounding region. Like many towns in Adıyaman Province, Harmanli's economy is primarily based on agriculture and small-scale trade, with the community maintaining traditional settlement patterns typical of rural Anatolia.