Palenque is a corregimiento (administrative subdivision) located in Santa Isabel District, Colón Province, Panama. It serves as the administrative seat of Santa Isabel District.
According to census records, Palenque had a population of 281 in 1990, which grew to 400 by 2000 and 404 by 2010. The town functions as the district's governmental and administrative center for the surrounding region in Colón Province.