Santo Domingo is a municipality located in the Chontales Department of Nicaragua. The municipality covers an area of 681.7 square kilometers (263.2 square miles) and had an estimated population of 14,460 residents as of 2023.
Santo Domingo is primarily known as a mining town, with several small gold mines operating throughout the region. This mining activity forms the economic foundation of the municipality and distinguishes it as an important center for mineral extraction in the department.