Niquinohomo is a municipality located in the Masaya Department of Nicaragua. It serves as a local administrative center within this region.
The city is notable for housing the Church of Saint Ann, which is recognized as the oldest extant church in Nicaragua. The church is dedicated to the town's patron saint.
Additionally, Niquinohomo is historically significant as the birthplace of Augusto César Sandino. He is a prominent figure after whom the Sandinista movement was named.