Malpaisillo is a town in Nicaragua that serves as the municipal seat of Larreynaga, the second largest municipality in the León Department. The municipality lies in the western part of the country, within the department of León.
Larreynaga municipality has an estimated population of 33,117, and its population is reported to be growing at a rate of about 2.22% per year. As the seat of the municipality, Malpaisillo is its administrative center.