San Francisco de Cuapa is a municipality located in the northeast section of the Chontales Department in Nicaragua. The region covers an area of approximately 277 km² (107 sq mi).
The municipality was officially established on July 30, 1997, after previously being part of the municipality of Juigalpa. The local economy is primarily driven by agriculture and cattle ranching. The population is predominantly Catholic, with 99% of residents identifying with the faith.