Santo Domingo is a town and municipality located in San Luis Potosí, a state in central Mexico. It is part of the administrative divisions within the San Luis Potosí region.
As a municipality, Santo Domingo functions as both a settlement and a local administrative unit within the state. The town serves as the municipal seat, governing the surrounding rural and urban areas within its jurisdiction. Like many municipalities in San Luis Potosí, Santo Domingo reflects the region's mixed landscape of central Mexican terrain.