Mazzarino is a city and comune located in the province of Caltanissetta in Sicily, Italy. Situated in the interior of the island, it is part of the Sicilian administrative region and falls within the jurisdictional boundaries of the Caltanissetta province.
As a comune, Mazzarino functions as a municipality within Sicily's administrative structure. The city represents one of the numerous municipalities that comprise the Caltanissetta province, contributing to the region's diverse network of settlements and communities across central Sicily.