Casaletto Vaprio is a comune (municipality) in the Province of Cremona, in the Italian region of Lombardy. It is located about 35 kilometres (22 mi) east of Milan and about 45 kilometres (28 mi) northwest of Cremona.
The comune is part of the Cremona provincial administrative area within Lombardy, placing it in northern Italy between the regional capital of Milan and the provincial capital of Cremona.
Notable natives of Casaletto Vaprio include the composer Stefano Pavesi.