Oppido Mamertina is a town and comune in the province of Reggio Calabria, in the Calabria region of southern Italy. It is located about 62 kilometres (39 mi) northeast of Reggio Calabria and about 120 kilometres (75 mi) southwest of Catanzaro.
The town is one of the comuni that make up the province of Reggio Calabria, the southernmost province on the Italian mainland. Its position places it in the interior of Calabria, between the regional capital and the provincial capital of Catanzaro.