Alfedena is a comune in the province of L'Aquila, within the Abruzzo region of central Italy. It sits in the upper Sangro valley, near the Monti della Meta mountain chain.
The town lies within the Abruzzo, Lazio and Molise National Park, one of Italy's protected areas in the central Apennines. Its position in the upper Sangro valley places it among the mountainous terrain of the region.