Macuelizo is a municipality located in the department of Santa Bárbara in Honduras. The region covers an area of 413.1 km² (159.5 sq mi) and, according to the 2013 national census, had a population of 34,401 inhabitants.
Situated within the fertile Quimistán Valley, the municipality is watered by the Culupa and Chamelecón Rivers. The Pan American Highway passes through the area, which contains significant natural resources and mineral deposits, specifically gold and antimony.