Villamesías is a municipality in Spain, located in the province of Cáceres within the autonomous community of Extremadura. It lies in the western-central part of the country, near the border with Portugal.
The municipality is small and rural, with a population recorded as 344 inhabitants in the 2006 census conducted by Spain's National Statistics Institute (INE). Like many settlements in this part of Extremadura, it is characterized by a low population density and a setting typical of the region's dehesa landscape.
Villamesías is administered as a municipality, the basic local administrative unit in Spain, which includes the town itself and its surrounding territory.