Valle de Santa Ana is a municipality in Spain, located in the province of Badajoz within the autonomous community of Extremadura. It lies in the western part of the country, near the border with Portugal.
According to the 2006 census conducted by the Instituto Nacional de Estadística (INE), the municipality had a population of 1,230 inhabitants. Like many small municipalities in rural Extremadura, it is characterised by a low population density and a settlement pattern typical of the region's villages.