Santiago de Alcántara is a municipality in the province of Cáceres, in the autonomous community of Extremadura, Spain. It is a small rural settlement in western Spain, near the border with Portugal.
According to the 2006 census carried out by Spain's national statistics institute (INE), the municipality had a population of 724 inhabitants. This figure reflects the modest size of the community and its character as a sparsely populated municipality typical of parts of inland Extremadura.