Santa Ana is a municipality in the province of Cáceres, in the autonomous community of Extremadura, Spain. It is located in the western-central part of the country, within the broader Extremadura region that borders Portugal to the west.
The municipality covers an area of 34.99 square kilometres (13.51 square miles). As of 2011, it had a population of 294 people, making it a small and sparsely populated rural community.
Its administrative status as a municipality places it among the many small local entities that make up the province of Cáceres. The combination of a modest land area and a low population reflects the dispersed settlement pattern typical of parts of rural Extremadura.