Gargantilla is a municipality in Spain, located in the province of Cáceres within the autonomous community of Extremadura. It lies in the western-central part of the country, near the border with Portugal.
According to the 2006 census conducted by the Instituto Nacional de Estadística (INE), Gargantilla had a population of 450 inhabitants. The municipality is one of many small, sparsely populated settlements that characterise the rural landscape of Extremadura.