Ossó de Sió is a village in the province of Lleida, in the autonomous community of Catalonia, Spain. It is located in the comarca of Urgell, in the western part of Catalonia, on the Sió river plain.
The village is one of several small settlements that make up the municipality of Ossó de Sió, which also includes the hamlets of Bellveí and Mont-roig. The municipality covers an area of about 25 square kilometres and has a population of around 200 people.
The village is centred on the church of Sant Salvador, a Romanesque building that dates from the 12th century. The surrounding landscape is characterised by dryland farming, with fields of cereals, olives and almonds typical of the Urgell plain.