Mediona is a municipality in the comarca of Alt Penedès, in the province of Barcelona, Catalonia, Spain. It lies in the northeastern part of the Iberian Peninsula, within the autonomous community of Catalonia.
As a municipality, Mediona forms part of the administrative structure of Alt Penedès, a comarca known for its wine-producing traditions. The town is one of several municipalities that make up this region in the province of Barcelona.