Casaseca de Campeán is a municipality in the province of Zamora, within the autonomous community of Castile and León, Spain. It is located in the northwestern part of the country, in a region characterised by a continental Mediterranean climate and a landscape of plains and rolling terrain typical of the Duero basin.
The municipality is small and rural, with a recorded population of 121 inhabitants according to the 2009 census conducted by the Instituto Nacional de Estadística (INE). Like many villages in the province of Zamora, it has experienced a low and declining population base, and its economy has traditionally been tied to agriculture.
Casaseca de Campeán is one of numerous small municipalities that make up the province of Zamora, a largely rural area of Castile and León known for its historic towns, Romanesque churches, and proximity to the Portuguese border. The village lies within the comarca of Tierra del Vino, a district historically associated with wine production.