Berzosa de Bureba is a municipality and town in the province of Burgos, within the autonomous community of Castile and León, Spain. It lies in the Bureba comarca, a district in the north of the province whose name the town shares.
The municipality is small and sparsely populated. According to the 2004 census carried out by Spain's National Statistics Institute (INE), it had a population of 48 inhabitants. As with many rural settlements in this part of Castile and León, the recorded population is low, reflecting the modest size of the community.
Berzosa de Bureba is one of the numerous small municipalities that make up the province of Burgos, and its administrative status as both a municipality and a town means it has its own local governing body. The town's name links it directly to the surrounding Bureba district, the geographical area in which it is situated.