Layos is a municipality in the province of Toledo, within the autonomous community of Castile-La Mancha, Spain. It lies in the central part of the country, near the city of Toledo.
According to the 2006 census conducted by the Instituto Nacional de Estadística (INE), Layos had a population of 378 inhabitants, making it a small, sparsely populated municipality.
The locality is known for the Layos Sarcophagus, a paleochristian sarcophagus discovered there in 1627.