Isuerre is a municipality located in the province of Zaragoza, in the autonomous community of Aragon, Spain. It is a small, sparsely populated settlement in this part of northeastern Spain.
According to the 2004 census carried out by the Instituto Nacional de Estadística (INE), the municipality had a population of 53 inhabitants. This figure reflects the character of Isuerre as a very small rural municipality, typical of the depopulated areas found across inland Aragon.