Murillo de Río Leza is a village and municipality in the province and autonomous community of La Rioja, in northern Spain. It lies within the Ebro river basin, and its name references the Leza, a tributary of the Ebro that flows through the area.
The municipality covers an area of 46.06 square kilometres (17.78 square miles). As of 2011, it had a population of 1,835 people. Like much of La Rioja, the surrounding landscape is shaped by agriculture and river valleys, with the region best known for its wine production.