Las Matas de Farfán is a town in the San Juan Province of the Dominican Republic. It is one of the communities that make up the province in the country's western interior.
The town is notable as the birthplace of a number of current and former Major League Baseball players, including Jean Segura, Juan Encarnación, Roberto Novoa, Odalis Pérez, Ramón Santiago, and Valerio de los Santos.
During the Haitian occupation of 1822 to 1844, the town was officially designated as Las-Mathas.