Mayarí is a municipality and town in Holguín Province, Cuba. It is located in the eastern part of the country, within one of Cuba's largest provinces by area.
The municipality is centred on the town of Mayarí, which serves as its administrative seat. Like other Cuban municipalities, it functions as a local government unit encompassing both the urban settlement and the surrounding rural areas.
Mayarí lies in a region of Holguín Province known for its mountainous terrain and agricultural activity, though the town itself sits in the valley area near the Sierra de Nipe. The surrounding municipality is one of the larger in the province by land area.