Santa Familia is a village situated along the Belize River in Cayo District, Belize. According to the 2010 census, the village had a population of 1,598 people living in 321 households.
As a settlement in Cayo District, Santa Familia is part of the inland region of Belize, which is characterized by its river systems and proximity to the Maya Mountains. The village's location along the Belize River has historically made it accessible via water transport, a significant feature in the region's geography and connectivity.