Paraguaçu Paulista is a municipality located in the southwestern region of the state of São Paulo, Brazil. Situated within the Middle Paranapanema Valley, it belongs to the Microregion of Assis and covers a total area of 1,001.3 square kilometers.
The city has a population of 45,945 residents. It ranks as the second-largest population within its microregion and the third-largest in its mesoregion. The municipality is located approximately 422 kilometers from the state capital of São Paulo.