São Francisco de Paula is a municipality in the Serra Gaúcha region of the state of Rio Grande do Sul, Brazil. It lies about 112 km (70 mi) from Porto Alegre, the state capital.
The municipality covers roughly 3,289.7 km² (1,270.2 sq mi), making it extensive in area. Its population was estimated at 21,801 as of 2020. The municipality was originally created on December 23, 1902.