Santa Margarida do Sul is a municipality in the state of Rio Grande do Sul, in the Southern Region of Brazil. It is one of the many municipalities that make up this southern Brazilian state, which borders Uruguay and Argentina.
The municipality is situated in the southernmost part of Brazil, a region characterized by its temperate climate and its history of European settlement, particularly by Portuguese, German, and Italian immigrants. Rio Grande do Sul is Brazil's southernmost state and shares borders with the Brazilian state of Santa Catarina to the north and with Uruguay to the south.
Like other municipalities in the state, Santa Margarida do Sul forms part of the local administrative structure of Rio Grande do Sul, with its own municipal government. The area is part of the broader cultural and geographic landscape of southern Brazil.