Panagyurishte is a town located in the Pazardzhik Province of southern Bulgaria. Situated within a small valley in the Sredna Gora mountains, it sits approximately 91 km east of Sofia and 43 km north of Pazardzhik. The town serves as the administrative center for the Panagyurishte Municipality.
The area is an important industrial and economic hub, specifically serving as the center of the Bulgarian optical industry and a major site for copper extraction and processing. As of the 2021 census, the town had a population of 15,275.
Panagyurishte holds significant historical importance as the center of the 1876 April Uprising against the Ottoman Empire. Additionally, the site is notable for the discovery of the Thracian Panagyurishte Treasure near the town.