Santa Rosa is a city in the center-north of Mendoza Province, Argentina. It lies on the northern shore of the Tunuyán River, along National Route 7, to the south-east of the provincial capital, Mendoza. It is the head town of the Santa Rosa Department.
According to the 2001 census conducted by INDEC, the city had a population of 15,818 inhabitants. Its position on National Route 7 places it on a major road corridor linking it with Mendoza and the wider region.