San Cosme is a town in Corrientes Province, Argentina. It is the capital of San Cosme Department, the administrative division that bears the same name.
The town is located in the north of Corrientes Province, in the Mesopotamia region of northeastern Argentina, an area bordered by the Paraná and Uruguay rivers. Corrientes Province sits in a subtropical zone, and the provincial capital, also named Corrientes, lies to the west of San Cosme along the Paraná.
As the seat of its department, San Cosme serves as the local administrative center for the surrounding area. The town shares its name with the department it heads, a common arrangement in Argentina's provincial administrative structure.