Capilla del Señor is a city in the northern part of Buenos Aires Province, Argentina. It serves as the administrative seat of Exaltación de la Cruz Partido, a district bounded by the partidos of Zárate, Campana, Pilar, Luján, San Antonio de Areco, and San Andrés de Giles.
The city lies about 82 kilometres (51 mi) from Buenos Aires. Other nearby distances include 24 km (15 mi) from Zárate, 27 km (17 mi) from Pilar, 30 km (19 mi) each from Campana and Luján, 47 km (29 mi) from San Antonio de Areco, and 49 km (30 mi) from San Andrés de Giles.
Capilla del Señor was designated by former president Carlos Saúl Menem as the "First National Historical Town" in Argentina.