La Crosse is a city located in La Crosse County, Wisconsin, in the United States. It serves as the county seat and is situated along the banks of the Mississippi River. As of the 2020 census, the city had a population of 52,680.
The city is notable for being the most populous municipality on Wisconsin's western border. The broader La Crosse–Onalaska metropolitan area has an estimated population of approximately 140,000 residents.