Keshena is a census-designated place (CDP) located in Menominee County, Wisconsin, in the United States. It serves as the county seat for the region and is situated on the Menominee Indian Reservation.
The community was named after an Indian chief, derived from the Menominee name Kesīqnaeh, which translates to "Swift Flying." According to the 2020 census, Keshena had a population of 1,257 residents.