St. Louis is an independent city located in the U.S. state of Missouri. It is situated near the confluence of the Mississippi and Missouri rivers.
The city proper had a population of 301,578 as of 2020. Its metropolitan area extends into Illinois and has an estimated population of over 2.8 million people. St. Louis represents the largest metropolitan area in Missouri and the second-largest in Illinois, while its combined statistical area ranks as the 20th-largest in the United States.