Port Saint Lucie is a city located in St. Lucie County, Florida, within the United States. Situated along the Treasure Coast, it lies approximately 125 miles southeast of Orlando and 113 miles north of Miami.
The city is the most populous municipality in St. Lucie County and ranks as the sixth-most populous city in the state of Florida. As of the 2020 census, its population was recorded at 204,851. Port Saint Lucie serves as a principal city within both the Port St. Lucie metropolitan statistical area and the Miami-Fort Lauderdale-Port St. Lucie combined statistical area.