Merkezefendi is a municipality and district located in the Denizli Province of Turkey. It covers a total area of 336 km2 and had a recorded population of 336,818 as of 2022.
The district was established following a local government reorganization in 2013, which partitioned the former central district of Denizli. During this process, portions of the original central district were allocated to both Merkezefendi and the Pamukkale District. The name of the municipality is derived from Merkez Efendi, a Sufi figure from the 16th century.