Medenine is a major town located in the south-eastern region of Tunisia. It serves as the administrative capital of the Medenine Governorate and is situated approximately 77 kilometres (48 mi) south of the port of Gabès and the Island of Djerba.
The town is positioned along the primary transportation route leading toward Libya. It functions as a significant regional hub within its governorate, providing a key point of interest for travelers moving through the southeastern portion of the country.