São Mamede de Infesta, often referred to simply as São Mamede, is a civil parish located in the municipality of Matosinhos within the Greater Porto area of Portugal. Situated just north of the city of Porto, the area serves as a populated residential zone with approximately 28,000 inhabitants.
The administrative status of the parish underwent significant changes in recent years. In 2013, it merged into the new civil parish of São Mamede de Infesta e Senhora da Hora; however, it was subsequently restored as an independent entity in 2025.