Dera Ghazi Khan, often abbreviated as D. G. Khan, is a city located in the southwestern part of Punjab, Pakistan. It is situated west of the Indus River within the Derajat region.
The city serves as the administrative headquarters for both the Dera Ghazi Khan district and its eponymous division. As of 2023, it ranks as the 16th most-populous city in Punjab and the 23rd most-populous city in Pakistan.