Enrile is a surname associated with several notable individuals in Philippine and Spanish history. The name is linked to various figures in politics, law, and sports.
Notable people with the surname include Arturo Enrile (1940–1998), Juan Ponce Enrile (1924–2025), and Sally Ponce Enrile, who are all Filipino politicians. Other individuals associated with the name include Ronjay Enrile, a Filipino basketball player, and Pasqual Enrile y Alcedo, who served as a Spanish governor-general of the Philippines from 1772 to 1836.